Saturday, January 17, 2015

Omega-3 and liver enzymes.

Question: I have eaten omega-3 for 2 weeks, then I went for blood examination, it appears that the decrease in liver enzymes. I suspected that the result associated with omega-3 or not?

Answer: Omega-3 means omega-3-polyunsaturated fatty acid (PUFA). Study on effects of omega-3 to the liver did not result in the same direction.
However, there are studies from systematic literature review and meta-analysis that collecting the result of studies about patients with non alcoholic fatty liver that often occurs in people with overweight and insulin resistance.

It found that PUFA can reduce the amount of liver fat and can reduce liver enzyme named AST (aspartate aminotransferase) significantly, and PUFA is likely to reduce the liver enzyme named ALT (alanine aminotransferase) but not clinically significant.
However we still do not know the accurate dose of PUFA for decreasing fat or reducing levels of liver enzymes.


The study did not gather information from randomized controlled trials. So the result of study is not enough reliability and may need more support, information, education in the future. Thus, from the results of the study now it may be possible that PUFA are useful in reducing fat in the liver and reducing liver enzymes (AST) in patients with non alcoholic fatty liver

References:
Parker HM, Johnson NA, Burdon CA, Cohn JS, O'Connor HT, GeorgeJ. Omega-3 supplementation and non-alcoholic fatty liver disease: a systematic review and meta-analysis. J Hepatol 2012; 56 (4): 944-51.

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