Osteoarthritis is a degenerative condition of the joints and tissues. It have tension of muscle and pain, later the joint swelling etc. When late-stage symptoms, the joints will look malformed.
Besides medication to relieve pain or inflammation in order to prevent the spread of disease. There are supplements that may be helpful.
Glucosamine sulfate is a compound found in the form of drugs and supplements.
Dose generally is 1500 mg daily.
Studies in vitro, Found that glucosamine sulfate has a stimulating effect on the synthesis and inhibit the degradation of Proteoglycans, which is an important component in cartilage that acts as a cushion between the joint of bones. And glucosamine has a mild anti-inflammatory effects as well.
Clinical studies (studies in humans) show results similar to the treatment of non-steroidal anti-inflammatory steroids. (NSAIDs), but the initial results from glucosamine are slower and relief of symptoms are gradually better, not as fast as drug use (=NSAIDS). The results of relieving the symptoms range from moderate to a maximum. Report: 14 in 15 issues benefits of Glucosamine sulfate over the non-steroidal anti-inflammatory steroids (NSAIDs) are glucosamine can delay the movement of the knee joint toward each other. This result is clearly seen after 1 year of using glucosamine and more apparently after 3 years of continuous use.
The most common adverse reactions are nausea, diarrhea, heartburn, abdominal pain. Other symptoms are less common are headaches, dizziness, insomnia, edema, dermatitis, tachycardia.
Precautions: Glucosamine should not be used in people who are allergic to seafood. Because glucosamine may be prepared from marine animals which can cause severe allergic reactions.
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