Wednesday, September 30, 2015

Can cyproheptadine be given 1 tablet per day for appetite?

Question: Dosage of cyproheptadine for appetite usually 1 tablet 3 times a day. Is the effectiveness of appetite reduced or not, if it is given orally 1 tablet once daily?

Answer: cyproheptadine is an anti-histamine. It is used to treat allergy symptoms. Cyproheptadine has been used to stimulate appetite.

There are reports of clinical studies in healthy volunteers about efficiency in stimulating appetite. The dose of cyproheptadine used is 4 mg 3 times a day. It is found that the volunteers had appetite and weight gain when compared to placebo.

However, no information on the effectiveness of cyproheptadine for stimulate the appetite, when the drug is eaten 4 mg once daily.

References:
1. Noble RE. Effect of cyproheptadine on appetite and weight gain in adults. JAMA.1969; 209: 2054-5.
2. Silverstone T, Schuyler D. The effect of cyproheptadine on hunger, calorie intake, and body weight in man. Psychopharmacologia. 1975; 40: 335-40.




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