Thursday, September 12, 2013

Nsaids with G6PD

Question: I am G6PD.  I have back pain due to sport since two days ago.  I used topical drug but it was not improved.  I want to take oral medication.  What medicine should be taken?
Answer: For back pain, you can take analgesics such as Nsaids as diclofenac, ibuprofen (both oral and topical) .  But aspirin should not be used (it causes bleeding).  You can use analgesic  in combined with muscle relaxant drugs such as  Tolperisone, eperisone or orphenadrine.  These medications with less risk to G6PD.

Precaution- The two main of adverse drug reaction (ADRs) associated with NSAIDs related to the gastrointestinal (GI)  and kidney. The drugs cause gastric bleeding and form ulceration in the gastric epithelium, and affect to renal function. Therefore This medication should be taken immediately after meals, and use caution in patient with renal dysfunction.


G6PD deficiency is an inherited condition in which the body doesn't have enough of the enzyme glucose-6-phosphate dehydrogenase, (or G6PD), which helps red blood cells (RBCs) function normally. This deficiency can cause hemolytic anemia, it usually happen after exposure to certain medications, foods, or even infections.
Most people with G6PD deficiency don't have any symptoms, while others develop symptoms of anemia only after RBCs have been destroyed, a condition called hemolysis. In these cases, the symptoms will disappear once  after the cause is removed. In rare cases, G6PD deficiency leads to chronianemia.

No comments:

Post a Comment