Metoclopramide, Hyoscine And Domperidone

Question: Can we take plasil (metoclopramide) together with buscopan (hyoscine), or take buscopan with domperidone?

Answer: Plasil can increase the movement in the gastrointestinal tract, by acting through neurotransmitters (=acetylcholine), and inhibiting the function of the neurotransmitter (=dopamine) in the gastrointestinal tract. Plasil also has anti-vomiting because it can inhibit the function of the neurotransmitter (=dopamine) in and out of the brain.

Buscopan can reduce the mobility of gastrointestinal tract, by acting through inhibiting the function of neurotransmitter (=acetylcholine). So buscopan should not be administered together with plasil. Buscopan can be used to relieve abdominal pain.

Domperidone increases mobility in the gastrointestinal tract, by inhibiting the function of the neurotransmitter (=dopamine) outside the brain. When giving buscopan together with domperidone may antagonistic effect on the movement of the digestive tract. So both of them should not be used together.

Reference:

1. Lacy CF, Armstrong LL, Goldman MP, Lance LL, editors. Drug Information Hand, 21st ed. Ohio: Lexi-comp; 2012-2013.

2. Tatro DS, editor. Drug Interaction Facts. St. Louis, Missourit: Wolter Kluwer Health; 2013.

3. Interactions-check. Drug-Drug Interactions: domperidone. Available at: http://www.drugs.com/interactions-check.php?drug_list=1612-0,2047