Question: What is antidote
of tramadol and how much dose used in children and adults?
Answer: Tramadol is a type
of opioids used to relieve pain. The drug is used as an antidote of opioids is
opioid antagonists.
However, tramadol overdose should be treated
symptomatically. Such as: Treatment for the respiratory (resuscitation) and circulatory systems
and prevention for seizures.
Opioid antagonist is used as an antidote is naloxone. However,
the drug does not treat all the symptoms and the drug can cause seizures. The
seizures can be controlled by diazepam.
.
Dosage of naloxone in children
Initial dose is 0.01 mg / kg by
intravenous (IV bolus) then increase to 0.1 mg / kg, repeated every 2-3
minutes. Maximum dose is 2 Mg.
.
Dosage of naloxone in adults
IV bolus 0.4 to 2 mg, repeated every
2-3 minutes. Maximum dose is 10 mg.
If the patient could not be
administered intravenously, can be considered for subcutaneous injection or
intramuscular injection instead, and using the same dosage.
And if the patient has been
administered to 10 mg of naloxone, but the symptoms did not improve. It may be
needed to determine the cause of the symptoms once again that caused by
overdose of tramadol or not.
Reference:
1. Wermeling DP. Review of naloxone
safety for opioid overdose: practical considerations for new technology and
expanded public access. Ther Adv Drug Saf 2015; 6 (1): 20-31.
2. Kastrup EK, Johnson PB, Meives CA,
Willians AL, Moore LL, Bush AJ, et al. Drug Facts and Comparisons. St. Louis:
Wolters Kluwer Health, 2012.
3. American Pharmacists Association.
Drug Information Handbook with International Trade Names Index. 22th ed. Ohio:
Lexi-Comp Inc, 2013.
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