Question: What is the mechanism of drug interaction
between antibiotics and oral contraceptives?
Answer: There are several mechanisms of drug
interaction between antibiotics and oral contraceptives, depending on the type
of antibiotics.
Such as:
Penicillins and Tetracyclines
will reduce the absorption of oral contraceptives. By inhibiting bacteria in
the intestine that affects an enzyme used in the process of enterohepatic recirculation.
And it resulted in decrease in level of oral contraceptives.
Rifampicin is an enzyme
inducer. It makes an enzyme in the liver to eliminate estrogenic and progestational
component in oral contraceptives from the body faster.
References:
http://www.ncbi.nlm.nih.gov/pubmed/12063491
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